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Physiol. Genomics 1: 165-175, 1999. First published November 11, 1999;
1094-8341/99 $5.00
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HEYEN, D. W. || LEWIN, H. A.
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Received 12 May 1999; accepted in final form 15 October 1999.
Physiological Genomics 1:165-175 (1999)
1094-8341/99 $5.00 1999 American Physiological Society

A genome scan for QTL influencing milk production and health traits in dairy cattle

D. W. HEYEN1; J. I. WELLER2; M. RON2; M. BAND1; J. E. BEEVER1; E. FELDMESSER2; Y. DA1; G. R. WIGGANS3; P. M. VANRADEN3 and H. A. LEWIN1

1 Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801
2 Institute of Animal Sciences, Agricultural Research Organization, the Volcani Center, Bet Dagan 50250, Israel
3 United States Department of Agriculture-Agricultural Research Service, Animal Improvement Programs Laboratory, Beltsville, Maryland 207052350

Heyen, D. W., J. I. Weller, M. Ron, M. Band, J. E. Beever, E. Feldmesser, Y. Da, G. R. Wiggans, P. M. VanRaden, and H. A. Lewin. A genome scan for QTL influencing milk production and health traits in dairy cattle. Physiol. Genomics 1: 165175, 1999.A genome scan was conducted in the North American Holstein-Friesian population for quantitative trait loci (QTL) affecting production and health traits using the granddaughter design. Resource families consisted of 1,068 sons of eight elite sires. Genome coverage was estimated to be 2,551 cM (85%) for 174 genotyped markers. Each marker was tested for effects on milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, and productive herd life using analysis of variance. Joint analysis of all families identified marker effects on 11 chromosomes that exceeded the genomewide, suggestive, or nominal significance threshold for QTL effects. Large marker effects on fat percentage were found on chromosomes 3 and 14, and multimarker regression analysis was used to refine the position of these QTL. Half-sibling families from Israeli Holstein dairy herds were used in a daughter design to confirm the presence of the QTL for fat percentage on chromosome 14. The QTL identified in this study may be useful for marker-assisted selection and for selection of a refined set of candidate genes affecting these traits.

genomics; lactation; mastitis






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